Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Manganese Catalyzed α-Olefination of Nitriles by Primary Alcohols

Manganese Catalyzed α-Olefination of Nitriles by Primary Alcohols
David Milstein, Subrata Chakraborty, Yehoshoa Ben-David, Uttam Kumar Das
Catalytic α-olefination of nitriles using primary alcohols, via dehydrogenative coupling of alcohols with nitriles, is presented. The reaction is catalyzed by a pincer complex of an earth-abundant metal (manganese), in the absence of any additives, base, or hydrogen acceptor, liberating dihydrogen and water as the only byproducts.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b06993

DOI: 10.1021/jacs.7b06993

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