Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Praseodymium(III)-Catalyzed Regioselective Synthesis of C3-N-Substituted Coumarins with Coumarins and Azides

Praseodymium(III)-Catalyzed Regioselective Synthesis of C3-N-Substituted Coumarins with Coumarins and Azides
Jiu-ling Li, Ying-Chun Wang, Da-chao Hu, Ying-ming Pan, Heng-Shan Wang, Xin-ping Liang
A series of C3-N-substituted coumarins were synthesized in good yields directly from coumarins and azides in the presence of Pr(OTf)3 without any additives or ligands needed. The selected compounds 3a, 3c–e, 3g, 3i, 3q, 3u, and 3v exhibited good anticancer activities against MGC-803, A549, and NCI-H460 cell lines with IC50 in the range 8.75–38.54 μmol L–1.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01410

DOI: 10.1021/acs.joc.7b01410

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