5 years ago

Stable and Multifunctional Dye-Modified Black Phosphorus Nanosheets for Near-Infrared Imaging-Guided Photothermal Therapy

Stable and Multifunctional Dye-Modified Black Phosphorus Nanosheets for Near-Infrared Imaging-Guided Photothermal Therapy
Haidi Fu, Zhibin Li, Liping Tong, Yuetao Zhao, Xue-Feng Yu, Jiahong Wang, Wenhua Zhou, Lie Wu, Na Yang, Paul K. Chu, Haodong Cui, Huaiyu Wang
Nanomedicines intergrating both therapy and diagnosis functions provide a promising strategy for anticancer treatment. As novel two-dimensional materials, black phosphorus nanosheets (BPs) possess unique properties for biomedical applications, pratically for photothermal therapy (PTT) of cancer, but their lack of air and water stability may hinder their application. Herein, a covalent functionalization strategy based on Nile Blue (NB) dye via diazonium chemistry is established to modify BPs, not only enhancing the stability of BPs but also rendering BPs via near-infrared (NIR) fluorescence, forming a novel multifunctional nanomedicine with both PTT and NIR imaging capabilities. In vitro tests demonstrate that the dye-modified BPs (named NB@BPs) have good biocompatibility and exhibit strong PTT and NIR imaging efficiency. In vivo experiments show that the NB@BPs can mark the tumor site with red fluorescence and lead to efficient tumor ablation under NIR irradiation. These results reveal a potential BP-based nanomedicine with multiple functionalities that bode well for anticancer applications.

Publisher URL: http://dx.doi.org/10.1021/acs.chemmater.7b01106

DOI: 10.1021/acs.chemmater.7b01106

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.