3 years ago

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.

Dale Ding, Aaron S Dumont, David M Hasan, Joshua M Hare, Gary K Owens, Muhammad S Ali, Robert M Starke, Pascal Jabbour, Alejandra Martinez Lege, Crissey L Pascale, John W Thompson, Michal Toborek, Nohra Chalouhi
Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on vascular smooth muscle cell (VSMC) phenotypic modulation and pathogenesis of CAs is unknown. The goal of this study was to investigate whether CSE activates a NOX (NAPDH oxidase)-dependent pathway leading to VSMC phenotypic modulation and CA formation and rupture.

Publisher URL: http://doi.org/10.1161/ATVBAHA.117.310478

DOI: 10.1161/ATVBAHA.117.310478

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