3 years ago

Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats

Kazuo Nishigaki, Yoshiharu Ohsato, Minh Ha Ngo, Taiji Endo, Ariko Miyake, Ryosuke Sumi

Abstract

Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.

Publisher URL: https://link.springer.com/article/10.1007/s00705-018-3721-1

DOI: 10.1007/s00705-018-3721-1

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