3 years ago

A novel method for rapid molecular subgrouping of medulloblastoma.

Alexey Kozlenkov, Laura Garcia-Gerique, Nada Jabado, Angel M Carcaboso, Jaume Mora, Michael D Taylor, Pascal Johann, Isadora Lemos, Stefan M Pfister, Betty Luu, Andrés Morales La Madrid, Volker Hovestadt, Mark W Kieran, Cinzia Lavarino, Stella Dracheva, Alícia Garrido-Garcia, David T W Jones, Sara Perez-Jaume, Mariona Suñol, Ofelia Cruz, Vijay Ramaswamy, Marta Kulis, Jose I Martín-Subero, Carmen de Torres, Soledad Gómez
The classification of medulloblastoma into WNT, SHH, Group 3 and Group 4 subgroups has become of critical importance for patient risk-stratification and subgroup-tailored clinical trials. Here, we aimed to develop a simplified, clinically applicable classification approach that can be implemented in the majority of centers treating patients with medulloblastoma.

Publisher URL: http://doi.org/10.1158/1078-0432.CCR-17-2243

DOI: 10.1158/1078-0432.CCR-17-2243

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