3 years ago

Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation.

Michael Peter Janisiw, Marie-Therese Kurzbauer, Gregory P Copenhaver, Magdalena Mosiolek, Monica Pradillo, Peter Schlogelhofer, Claudia Kerzendorfer, Dieter Schweizer, Jason Sims, Cecilia Oliver, Rene Ladurner
Fanconi anemia (FA) is a human autosomal recessive disorder characterized by chromosomal instability, developmental pathologies, predisposition to cancer and reduced fertility. So far, nineteen genes have been implicated in FA, most of them involved in DNA repair. Some are conserved across higher eukaryotes, including plants. The Arabidopsis thaliana genome encodes a homologue of the Fanconi anemia D2 gene (FANCD2) whose function in DNA repair is not yet fully understood. Here we provide evidence that AtFANCD2 is required for meiotic homologous recombination. Meiosis is a specialized cell division that ensures reduction of genomic content by half and DNA exchange between homologous chromosomes via crossovers (COs) prior to gamete formation. In plants, a mutation in AtFANCD2 results in a 14% reduction of CO numbers. Genetic analysis demonstrated that AtFANCD2 acts in parallel to both MUTS HOMOLOG 4 (AtMSH4), known for its role in promoting interfering COs and MMS AND UV SENSITIVE 81 (AtMUS81), known for its role in the formation of non-interfering COs. AtFANCD2 promotes non-interfering COs in a MUS81-independent manner and is therefore part of an uncharted meiotic CO-promoting mechanism, in addition to those described previously.

Publisher URL: http://doi.org/10.1105/tpc.17.00745

DOI: 10.1105/tpc.17.00745

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