5 years ago

Stereocontrolled Synthesis of Left Halves of Halichondrins

Stereocontrolled Synthesis of Left Halves of Halichondrins
Jihoon Lee, Ning Ye, Yoshito Kishi, Kentaro Iso, Kenzo Yahata, Yanran Ai
A stereocontrolled synthesis of the left halves of halichondrins was reported. An intramolecular oxy-Michael reaction under basic conditions was used to construct the [6,6]-spiroketal in a stereocontrolled manner. With this approach, the left halves of halichondrins, homohalichondrins, and norhalichondrins were synthesized.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01284

DOI: 10.1021/acs.joc.7b01284

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