3 years ago

Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins

Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins
Huanfeng Jiang, JianXiao Li, Guangbin Jiang, Wanqing Wu, Chuanle Zhu
An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that the transformation might proceed via a stereo- and regioselective nucleophilic addition and C–H functionalization procedure.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01919

DOI: 10.1021/acs.orglett.7b01919

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