3 years ago

Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides via Carbene Migratory Insertion

Guojiao Wu, Yunpeng Gao, Qi Zhou, Jianbo Wang
A Pd-catalyzed oxygenative cross-coupling of ynamides and benzyl bromides has been developed. After subsequent hydrogenation, α,α-disubstituted amide derivatives were obtained in good yields. Migratory insertion of α-oxo palladium carbene species generated by intermolecular oxidation is proposed as the key step in this reaction. The study demonstrates the potential of ynamides as carbene precursors in Pd-catalyzed C-C bond-forming cross- coupling reactions.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201712795

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