3 years ago

脂溢性皮炎在中老年人群中的发病率及决定因素:鹿特丹研究

O.H. Franco, R.S. Ginger, T. Nijsten, L.M. Pardo, M.G.H. Sanders
脂溢性皮炎是一种常见的皮肤病,见于头皮、面部及胸部,主要表现为炎症和脂性鳞屑。虽然尚不清楚脂溢性皮炎的病因,但研究者认为马拉色氏酵母菌的过度生长是脂溢性皮炎的部分原因。若干其他因素也与此类疾病有关;年龄、性别、肥胖、肤色、压力、沮丧、教育程度、高血压、气候、皮肤干燥、饮酒以及吸烟等因素都与脂溢性皮炎有关,但相关性证据通常并无定论。该研究旨在确定与脂溢性皮炎有关的生活方式及生理因素。该研究中的数据来自针对荷兰中老年人群开展的鹿特丹研究,旨在研究这些之前报告的因素。研究依据在于,了解决定因素可以在脂溢性皮炎的病理生理学方面提供新的见解,以便采取预防策略和/或新的治疗方案。在鹿特丹研究中,5,498 位参与者进行了全身皮肤检查,其中 788 位罹患脂溢性皮炎。作者发现,男性、肤色浅、冬季以及全身干燥皮肤可增加脂溢性皮炎发病率,其他因素则与脂溢性皮炎无关。此外,作者分析了研究性别差异能否通过激素差异来解释,但他们发现激素与脂溢性皮炎之间并无关联。在已发现的关联中,干燥皮肤似乎最容易带来影响。因此,增强皮肤屏障可以作为脂溢性皮炎治疗中的一个目标。

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjd.16185

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