3 years ago

光疗祛痘:包含等级评估的缩减版科克伦系统综述

P. Posadzki, A.M. Layton, J. Car, A. Majeed, M. Car, R. Abbott, L.H. Gunn, J. Barbaric
寻常痤疮是一种常见的皮肤问题,可导致黑头、白头以及红斑。痤疮通常会留下非常难治的痘印。痤疮可能导致严重的心理和社交问题,包括自尊心受挫、焦虑、沮丧以及情绪低落。许多光疗法已试验用于治疗寻常痤疮,但其效果和安全性尚不明确。光疗法使用具有不同性质(比如波长和强度)的光。虽然具体机理尚未完全弄清,但有三个因素至关重要:光、感光剂(即:吸收并随后通过光激化的分子)以及通过激化产生的氧化应激。大家认为,这种氧化应激有助于破坏致菌痤疮并防止毛孔堵塞。该研究综述了不同的光疗祛痘试验。研究人员发现,有关使用光疗祛痘的高质量证据尚且缺乏。有证据表明甲基氨基酮戊酸盐光动力疗法(红光)有效,证据质量尚可。此外,有证据表明氨基酮戊酸光动力疗法(蓝光)在作为标准疗法治疗中度到重度痤疮方面有效,但证据质量不高。通过该综述,更加有必要确定标准化结果测量指标(定义治疗是否成功的方法)、扩大更高质量的研究规模并且充分报告未来研究。

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjd.16198

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