3 years ago

Back Cover: Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway

Back Cover: Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway
Lan-yue Zhang, Shun Huang, Kun Zhang, Chun Li, Li Lin, Li-hang Xiao, Yuan-yuan Chang, Jian Tang, Ren-ping Zhou, Wei Zhou, Zhi-yun Du, Min Chen
Mol. Nutr. Food Res. 2018, 62, 1700281DOI: 10.1002/mnfr.201700281Oral administration of aromatic-turmerone could reverse lipopolysaccharide (LPS)-induced memory disturbance and normalize glucose intake and metabolism in the brains of mice. Moreover, aromatic-turmerone significantly limits brain damage by inhibiting the activation of microglia and the generation of inflammatory cytokines. Further in vitro study reveals that aromatic-turmerone-targeted Toll-like receptor 4 (TLR4) mediates downstream signaling and lowers the release of inflammatory mediators.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mnfr.201870023

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