3 years ago

Combined Iron/Hydroxytriazole Dual Catalytic System for Site Selective Oxidation Adjacent to Azaheterocycles

Combined Iron/Hydroxytriazole Dual Catalytic System
for Site Selective Oxidation Adjacent to Azaheterocycles
Chaosheng Luo, Jeffrey F. Van Humbeck, Ryohei Kameyama, Julian C. Cooper
This report details a new method for site-selective methylene oxidation adjacent to azaheterocycles. A dual catalysis approach, utilizing both an iron Lewis acid and an organic hydroxylamine catalyst, proved highly effective. We demonstrate that this method provides complementary selectivity to other known catalytic approaches and represents an improvement over current heterocycle-selective reactions that rely on stoichiometric activation.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b12864

DOI: 10.1021/jacs.7b12864

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