3 years ago

Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cyclization of 1,6-Enynes with Aliphatic and Aromatic Alkenes

Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cyclization of 1,6-Enynes with Aliphatic and Aromatic Alkenes
Yu Shibata, Hiroki Ueda, Ken Tanaka, Koji Masutomi
It has been established that a cationic rhodium(I)/(R)-MeO-BIPHEP complex catalyzes the asymmetric [2 + 2 + 2] cyclization of 1,6-enynes with aliphatic and aromatic alkenes to produce chiral cyclic dienes through β-hydride elimination from rhodacycle intermediates. Thus, obtained chiral cyclic dienes could be converted to chiral spirocompounds without racemization.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01149

DOI: 10.1021/acs.orglett.7b01149

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