3 years ago

Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies

Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis,
Structural Characterization, and Cytotoxicity Studies
Tatiyana V. Serebryanskaya, Anna A. Vasileva, Viktor N. Sorokoumov, Matti Haukka, Alexander G. Tskhovrebov, Paul J. Dyson, Vladimir N. Mikhaylov, Richard Goddard, Tina Riedel
Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO2 results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.8b00072

DOI: 10.1021/acs.inorgchem.8b00072

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