3 years ago

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function.

Saige L Pompura, Margarita Dominguez-Villar
The PI3K/AKT signaling pathway is an essential node in mammalian cells that controls cell growth, migration, proliferation, and metabolism. During the last decade, a number of works have demonstrated an important role for the PI3K/AKT pathway in regulatory T cell development, function, and stability. This review summarizes our current knowledge of how the PI3K/AKT pathway regulates thymic and peripheral Treg generation and function, with an emphasis on translation of these observations to therapies targeting Tregs in several pathologies.

Publisher URL: http://doi.org/10.1002/JLB.2MIR0817-349R

DOI: 10.1002/JLB.2MIR0817-349R

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