3 years ago

Coupling of sterically demanding peptides by [small beta]-thiolactone-mediated native chemical ligation

Coupling of sterically demanding peptides by [small beta]-thiolactone-mediated native chemical ligation
Qiang Zhang, Leonard Breindel, Ning Yuan, Jiaping Weng, Huan Chen, Alexander Shekhtman, Yunxian Xiao, Pengcheng Gao
[small beta]-Thiolactones have enabled the sterically demanding peptidyl ligations of Val-Leu, Val-Val and Val-Pro using a one-pot NCL and desulfurization protocol.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/HT-EItIj7IQ/C7SC04744D

DOI: 2018/SC/C7SC04744D

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