Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Multicomponent Synthesis of Diverse o-Arylated Benzamides via o-Aminophenol (OAP) Directed C(sp2)-H Arylation

Multicomponent Synthesis of Diverse o-Arylated Benzamides via o-Aminophenol (OAP) Directed C(sp2)-H Arylation
Yi Zhang, Yunyun Liu, Jie-Ping Wan
o-Aminophenol (OAP) has been discovered as practical precursor of directing group (DG) in the palladium-catalyzed aromatic C–H arylation of benzamides. This newly identified, simple, and low cost DG has exhibited broad substrate tolerance in the rapid synthesis of various o-arylated benzamides via direct assemblies of benzoyl chlorides, aryl iodides, and different o-aminophenols in the form of step economical multicomponent reaction.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01375

DOI: 10.1021/acs.joc.7b01375

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.