3 years ago

Trifluoromethylthiolation-Based Bifunctionalization of Diazocarbonyl Compounds by Rhodium Catalysis

Trifluoromethylthiolation-Based Bifunctionalization of Diazocarbonyl Compounds by Rhodium Catalysis
Marvin Lübcke, Weiming Yuan, Kálmán J. Szabó
A new Rh-catalyzed, three-component reaction for the oxytrifluoromethylthiolation of α-diazoketones was developed. The SCF3 functionality was introduced using a stable dibenzenesulfonimide reagent under mild conditions. Alcohols, acetals, and ethers were used as the alkoxy sources. Cyclic ethers underwent a trifunctionalization reaction through the introduction of SCF3, OR, and N(SO2Ph)2 substituents in a single step.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02139

DOI: 10.1021/acs.orglett.7b02139

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