3 years ago

Trimodal system for in vivo skin cancer screening with combined OCT-Raman and co-localized optoacoustic measurements

Mikhail Mazurenka, Lea Behrendt, Steffen Emmert, Maik Rahlves, Merve Meinhardt-Wollweber, Bernhard Roth, Elias Blumenröther, Arthur Varkentin, Uwe Morgner
A new multimodal system for rapid, noninvasive in vivo skin cancer screening is presented, combining optical coherence tomography (OCT) and optoacoustic (OA) modalities to provide precise tumor depth determination with a Raman spectroscopic modality capable of detecting the lesion type and, thus, providing diagnostic capability. Both optoacoustic and Raman setups use wide field skin illumination to ensure the compliance with Maximum Permissible Exposure (MPE) requirements. The Raman signal is collected via the OCT scanning lens to maximize the signal-to-noise ratio (SNR) of the measured signal while keeping radiation levels below MPE limits. OCT is used to optically determine the tumor thickness and for volumetric imaging whereas optoacoustics utilizes acoustic signals generated by optical absorption contrast for thickness determination at potentially higher penetration depths compared to OCT. Preliminary results of first clinical trials using our setup are presented. The measured lesion depth is in good agreement with histology results, while Raman measurements show distinctive differences between normal skin and melanocytic lesions, and, moreover, between different skin areas. In future, we will validate the setup presented for reliable detection of pathophysiological parameters, morphology and thickness of suspicious skin lesions.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbio.201700288

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