3 years ago

Arynes in the Monoarylation of Unprotected Carbohydrate Amines

Arynes in the Monoarylation of Unprotected Carbohydrate
Amines
Mukul Mahanti, Kumar Bhaskar Pal, Ulf J. Nilsson
A CsF-mediated method has been developed for the N-arylation of amino sugars that affords good to excellent yields of arylated products under mild conditions involving the in situ generation of arynes. The reaction conditions tolerate a variety of common carbohydrate protecting groups and also performs exceptionally well on unprotected amino sugar derivatives. The reactions are scalable in moderate to good yields with broad scope.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03741

DOI: 10.1021/acs.orglett.7b03741

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