3 years ago

A Dual Binding Receptor for ER-phagy

A Dual Binding Receptor for ER-phagy
Noboru Mizushima

Selective autophagy of the endoplasmic reticulum (ER)—ER-phagy—is mediated by multiple receptors. In this issue of Developmental Cell, Smith et al. (2018) identify ER membrane protein CCPG1 as an ER-phagy receptor that interacts with autophagy-related proteins GABARAPs and FIP200 and ensures ER protein homeostasis, especially in pancreatic acinar cells.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30001-7

DOI: 10.1016/j.devcel.2018.01.001

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