3 years ago

Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds

Thermolysis-Induced Two- or Multicomponent Tandem
Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides:
Access to Diverse Sulfur-Containing
Functional Scaffolds
Shengfeng Wu, Zhihua Sun, Erkang Fan, Xiaofang Lei
Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03593

DOI: 10.1021/acs.orglett.7b03593

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