Transcription-Replication Conflicts: Orientation Matters
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.
Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)30876-0
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