3 years ago

Cobalt-Catalyzed Aerobic Cross-Dehydrogenative Coupling of C–H and Thiols in Water for C–S Formation

Cobalt-Catalyzed Aerobic
Cross-Dehydrogenative Coupling
of C–H and Thiols in Water for C–S Formation
Xin Huang, Yongqi Chen, Mingqi Gao, Bingxin Yuan, Heng Li, Panke Zhang, Shan Zhen, Lijuan Song, Guanyu Yang
Organosulfides have great significance and value in synthetic and biological chemistry. To establish a versatile and green methodology for C–S bond generation, we successfully developed a new aerobic cross-dehydrogenative coupling of C–H and S–H to synthesize aryl sulfides in water, utilizing CoPcS as the catalyst and O2 as the oxidant. This protocol shows great tolerance of a wide range of substrates. A large variety of organosulfur compounds were produced in modest to excellent yields.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02718

DOI: 10.1021/acs.joc.7b02718

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