Sensors and Actuators, B: Chemical
Sensors and Actuators, B: Chemical
5 years ago

Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen

Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen
In this work, a label-free electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA). Flower-like Ag/MoS2/rGO nanocomposites were employed as the signal amplification platform of the designed immunosensor for the first time. Due to the synergistic effect between molybdenum disulfide (MoS2), reduced graphene oxide (rGO) and Ag nanoparticles (NPs), Ag/MoS2/rGO nanocomposites could provide a high sensitivity for the label-free electrochemical immunosensor. The detection mechanism was based on the monitoring of the electrocatalytic current response change towards the reduction of hydrogen peroxide (H2O2) when immunoreaction occurred on the surface of the electrode modified with Ag/MoS2/rGO nanocomposites. Using amperometric i-t curve to record the electrocatalytic process, the proposed immunosensor achieved an ultrasensitive and specific detection of CEA with a low detection limit of 1.6 fg/mL. Under optimal conditions, the fabricated immunosensor exhibited acceptable reproducibility, selectivity and excellent stability. This designed immunosensor could provide an effective method in the clinical diagnosis of other tumor markers.

Publisher URL: www.sciencedirect.com/science

DOI: S0925400517313370

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.