3 years ago

Acquired resistance of ER- positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through post-translational downregulation of c-FLIP.

Iduna Fichtner, Fouad S Alchami, Richard Clarkson, Luke Piggott, Julia Mw Gee, Robert B Clarke, Peter J Barrett-Lee, Ladislav Andera, Bruno M Simões, Michael Becker, Timothy Robinson, Philippa Young, Maria dM Vivanco, Marco Piva, Angélica Santiago-Gómez, Christine Morris, Andreia M da Silva
One-third of ER-positive breast cancer patients who initially respond to endocrine therapy become resistant to treatment. Such treatment failure is associated with poor prognosis and remains an area of unmet clinical need.  Here we identify a specific post-translational modification that occurs during endocrine resistance and which results in tumour susceptibility to the apoptosis inducer TNF-Related Apoptosis-Inducing Ligand (TRAIL). This potentially offers a novel stratified approach to targeting endocrine resistant breast cancer.

Publisher URL: http://doi.org/10.1158/1078-0432.CCR-17-1381

DOI: 10.1158/1078-0432.CCR-17-1381

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