Journal of Physical Chemistry B
Journal of Physical Chemistry B
5 years ago

Combining Experimental and Simulation Techniques to Understand Morphology Control in Pentapeptide Nanostructures

Combining Experimental and Simulation Techniques to Understand Morphology Control in Pentapeptide Nanostructures
Alok Jain, Sandeep Verma, Christine Peter, Narendra Kumar Mishra
A controlled route toward biocompatible nanostructures has immense relevance for drug delivery and tissue engineering. We present an experimental–computational study identifying factors that govern the formation of well-defined aggregates by self-assembled pentapeptides, using single amino acid substitution. A subtle interplay between peptide rigidity/flexibility, hydrogen-bonding capacity, partitioning of aromatic side chains, and influence of dimerization determines the formation of ordered and disordered aggregate structures, and shifts the balance between the emergence of spherical or ill-defined morphologies.

Publisher URL: http://dx.doi.org/10.1021/acs.jpcb.7b06005

DOI: 10.1021/acs.jpcb.7b06005

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.