3 years ago

Physicochemical Transformations of ZnO Nanoparticles Dispersed in Peritoneal Dialysis Fluid: Insights into Nano–Bio Interface Interactions

Physicochemical Transformations of ZnO Nanoparticles Dispersed in Peritoneal Dialysis Fluid: Insights into Nano–Bio Interface Interactions
Anupam Guleria, Dinesh Kumar, Narayan Prasad, Mukesh Kumar Meher, Krishna Mohan Poluri
Absence of effective antibiotics for the treatment of infectious peritonitis along with the appearance of multidrug-resistance has prompted the use of antimicrobial nanoparticles to impart infection resistant properties to the existing peritoneal dialysis (PD) fluid. To explore this research perspective, we investigated the solubility and physicochemical transformations of zinc oxide (ZnO) nanoparticles (NPs) dispersed in PD fluid using nuclear magnetic resonance spectroscopy in conjunction with dynamic light scattering, transmission electron microscopy, Fourier transform infrared and UV–visible spectroscopy. Our results emphasize that ZnO NPs strongly interact with organic acids found abundantly in biological fluids (demonstrated here with lactic and citric acid) and further lead to the formation of bioconjugates. On the basis of the current detailed investigations, we propose that the surface coating of ZnO NPs would be required to impart agglomeration resistant properties and to inhibit the binding interactions of NPs, thus rendering their safe and efficient intraperitoneal use as antimicrobials.

Publisher URL: http://dx.doi.org/10.1021/acs.jpcc.7b04889

DOI: 10.1021/acs.jpcc.7b04889

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