F1000Research
F1000Research
4 years ago

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved]

Shabaana Khader, Shibali Das
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.

Publisher URL: https://f1000research.com/articles/6-741/v1

DOI: 10.12688/f1000research.10862.1

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