Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Asymmetric Total Synthesis of Nannocystin A

Asymmetric Total Synthesis of Nannocystin A
Yun He, Qiang Liu, Ping Hu
Nannocystin A is a novel 21-membered macrolactone isolated from myxobacterium Nanocystis sp. It is a potent elongation factor 1 inhibitor and inhibits cancer cell line growth at nanomolar concentrations. In this work, a concise asymmetric total synthesis of nannocystin A has been developed, which features Sharpless epoxidation, Stille coupling, and final macrolactamization.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01502

DOI: 10.1021/acs.joc.7b01502

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