Organic Letters
Organic Letters
5 years ago

Trifluoromethylation of Secondary Nitroalkanes

Trifluoromethylation of Secondary Nitroalkanes
Donald A. Watson, Amber A. S. Gietter-Burch, Vijayarajan Devannah
Using a commercially available Umemoto’s reagent, the metal-free trifluoromethylation of nitroalkanes is now possible. This method provides a general, high-yielding synthesis of α-(trifluoromethyl)nitroalkanes. The quaternary α-(trifluoromethyl)nitroalkanes obtained from this transformation can be elaborated to a variety of complex nitrogen-containing molecules, including α-(trifluoromethyl)amines.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01196

DOI: 10.1021/acs.orglett.7b01196

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