3 years ago

Leptin Replacement Reestablishes Brain Insulin Action in the Hypothalamus in Congenital Leptin Deficiency.

Martin Heni, Hubert Preissl, Hans-Ulrich Häring, Martin Wabitsch, Stephanie Kullmann, Jürgen Machann, Ralf Veit, Sabine Frank-Podlech, Andreas Fritsche, Jaana M Heinze, Julia von Schnurbein, Saqib Mahmood, Jaida Manzoor
Human obesity is associated with impaired central insulin signaling, and in very rare cases, severe obesity can be caused by congenital leptin deficiency. In such patients, leptin replacement results in substantial weight loss and improvement in peripheral metabolism.

Publisher URL: http://doi.org/10.2337/dc17-1867

DOI: 10.2337/dc17-1867

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