3 years ago

P-Chirogenic Xantphos Ligands and Related Ether Diphosphines: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation

P-Chirogenic Xantphos Ligands and Related Ether Diphosphines: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation
Anke Spannenberg, Jens Holz, Haijun Jiao, Katharina Rumpel, Armin Börner, Rocco Paciello
A series of P-chirogenic Xantphos ligands and related diaryl ether diphosphines have been synthesized by a modification of the well-established Jugé method. The approach consists of the in situ deboranation of the chiral ephedrine-based phosphinite before the P–C coupling takes place. The stereochemical integrity of the stereocenters of the diphosphines during synthesis, long-time storage, and catalytic application was evaluated. In the rhodium-catalyzed asymmetric hydrogenation of isophorone as a model substrate for industrially relevant prostereogenic enones with some of the diphosphines, almost complete conversion, high chemoselectivity, and 96% ee were achieved.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b01260

DOI: 10.1021/acscatal.7b01260

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