Journal of Psychiatric Practice
Journal of Psychiatric Practice
5 years ago

Antipsychotics Do Not Influence Neurological Soft Signs in Children and Adolescents at Ultra-High Risk for Psychosis: A Pilot Study

PITZIANTI, MARIABERNARDA; CASARELLI, LIVIA; PONTILLO, MARIA; VICARI, STEFANO; ARMANDO, MARCO; PASINI, AUGUSTO
Objective: Ultra-high risk for psychosis (UHR) is considered as the condition that temporally precedes the onset of psychotic symptoms. In addition to the core symptoms, patients with schizophrenia show motor abnormalities, also known as neurological soft signs (NSS), that are considered an endophenotype for psychotic disorders and particularly for schizophrenia. Antipsychotic medications do not appear to influence NSS in individuals with schizophrenia. However, NSS in UHR subjects have been poorly studied and, to date, we do not know what effects antipsychotics have in early treated UHR subjects. Therefore, we evaluated NSS in treated UHR subjects in comparison with drug-naive UHR subjects and a group of healthy control subjects and the effect of pharmacological treatment on early treated UHR children and adolescents.

Publisher URL: https://journals.lww.com/practicalpsychiatry/Fulltext/2019/05000/Antipsychotics_Do_Not_Influence_Neurological_Soft.3.aspx

DOI: 10.1097/PRA.0000000000000387

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