Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry
5 years ago

Advances in macrocyclic peptide-based antibiotics

Advances in macrocyclic peptide-based antibiotics
Macrocyclic peptide-based natural products have provided powerful new antibiotic drugs, drug candidates, and scaffolds for medicinal chemists as a source of inspiration to design novel antibiotics. While most of those natural products are active mainly against Gram-positive pathogens, novel macrocyclic peptide-based compounds have recently been described, which exhibit potent and specific activity against some of the most problematic Gram-negative ESKAPE pathogens. This mini-review gives an up-date on recent developments.

Publisher URL: www.sciencedirect.com/science

DOI: S0968089617310763

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