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5 years ago

Hydrogen Polysulfide Biosignal-Responsive Polymersomes as a Nanoplatform for Distinguishing Intracellular Reactive Sulfur Species (RSS)

Hydrogen Polysulfide Biosignal-Responsive Polymersomes as a Nanoplatform for Distinguishing Intracellular Reactive Sulfur Species (RSS)
Xiang Hao, Wei Sang, Jian Zhang, Qiang Yan
Reactive sulfur species (RSS) are a family of crucial biosignals for regulating cell processes. Among these, hydrogen polysulfide (H2Sn, n ≥ 2) is a hallmark of tumor suppressor activation and regarded as the actual regulator to mediate sulfur-related biology. However, high effective recognition of intracellular H2Sn is insurmountable due to its extremely low concentration and the disturbance of RSS analogues. Here an H2Sn-responsive macromolecule that can distinguish H2Sn from intracellular RSS through polymer degradation in ultrasensitive and highly selective manner is reported. This kind of polymers can further self-assemble into vesicular nanostructure. Upon cell uptake, they can be function as “all-in-one” H2Sn-nanoplatforms, in order to fulfill multiple ambitious tasks including monitoring the H2Sn biosynthetic pathways, unraveling the puzzles of H2Sn-mediated cellular events, and conducting H2Sn pathological milieu-specific drug delivery. A first paradigm of H2Sn biosignal-responsive polymersomes is designed and fabricated to function as an “all-in-one” nanoplatform to track intracellular H2Sn-mediated cellular events and to execute H2Sn pathological milieu-specific drug delivery.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201701601

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