4 years ago

Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery

Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
About one-fifth of cancer patients suffer from breast cancer worldwide. Polymeric nanoparticles play an important role in delivering chemotherapeutic agents in a controlled manner. Polylysine coated tamoxifen loaded poly(lactic-co-glycolic acid) nanoparticles were prepared using a single emulsion technique with subsequent non-covalently surface functionalization in order to improve nanoparticle-cell interaction and hence tamoxifen therapeutic effect. The obtained nanoparticles were fully characterized in terms of their physico-chemical properties as well of their in vitro performance against human breast adenocarcinoma cells. The successful incorporation of tamoxifen within the hydrophobic matrix of nanoparticles is evidenced by a high loading efficiency (86%). Furthermore, ideal size, morphology and hydrodynamic properties are observed being the proposed nanocarrier capable of display a valuable antiproliferative in vitro effect.

Publisher URL: www.sciencedirect.com/science

DOI: S0014305717309515

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.