3 years ago

Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion.

Fritz Krombach, Martin Holzer, Gabriele Zuchtriegel, Maximilian Lerchenberger, Matthias Fabritius, Johanna Schaubächer, Christoph A Reichel, Sandip Kanse, Andrej Khandoga, Bernd Uhl, Dominik Funken, Laura Mittmann, Kirsten Lauber, Stefan Zahler, Robert Fürst, Marc Praetner
Ischemia-reperfusion (I/R) injury significantly contributes to organ dysfunction and failure after myocardial infarction, stroke, and transplantation. In addition to its established role in the fibrinolytic system, plasminogen activator inhibitor-1 has recently been implicated in the pathogenesis of I/R injury. The underlying mechanisms remain largely obscure.

Publisher URL: http://doi.org/10.1161/ATVBAHA.117.309760

DOI: 10.1161/ATVBAHA.117.309760

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