3 years ago

Inhibitory Effect of Vascular Endothelial Growth Factor on the Slowly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes.

Zhenhao Lin, Wenlu Xing, Datun Qi, Guoyou Dai, Ganxin Yan, Wen Zhao, Xianpei Wang, Chuanyu Gao
Vascular endothelial growth factor (VEGF) exerts a number of beneficial effects on ischemic myocardium via its angiogenic properties. However, little is known about whether VEGF has a direct effect on the electrical properties of cardiomyocytes. In the present study, we investigated the effects of different concentrations of VEGF on delayed rectifier potassium currents (IK) in guinea pig ventricular myocytes and their effects on action potential (AP) parameters.

Publisher URL: http://doi.org/10.1161/JAHA.117.007730

DOI: 10.1161/JAHA.117.007730

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