5 years ago

Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics

Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics
James A. Cowan, Zhen Yu
Metal complexes that catalyze inactivation and degradation of biomolecular targets can be developed into novel therapeutics (catalytic metallodrugs) against a variety of diseases. Despite recent advances in the field, a lack of substrate selectivity is a major hindrance to the development of catalytic metallodrugs for application in clinical practice. Improved targeting can minimize nonselective activity and the potential for side effects. Herein, we focus on recent developments toward novel metal catalysts that exhibit substrate selectivity against a variety of therapeutically relevant biomolecules. Design strategies for developing selective catalytic metallodrugs are also highlighted. Catalytic targeting! The design and applications of catalytic metallodrugs as a novel therapeutic strategy are summarized and illustrated through examples of substrate-selective metal catalysts that target a variety of disease-related biomolecules. This strategy of promoting inactivation of a therapeutic target to a dysfunctional form may find promising applications in drug design and provide new modes of action of relevance to combination therapies.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701714

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