Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics

Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics
James A. Cowan, Zhen Yu
Metal complexes that catalyze inactivation and degradation of biomolecular targets can be developed into novel therapeutics (catalytic metallodrugs) against a variety of diseases. Despite recent advances in the field, a lack of substrate selectivity is a major hindrance to the development of catalytic metallodrugs for application in clinical practice. Improved targeting can minimize nonselective activity and the potential for side effects. Herein, we focus on recent developments toward novel metal catalysts that exhibit substrate selectivity against a variety of therapeutically relevant biomolecules. Design strategies for developing selective catalytic metallodrugs are also highlighted. Catalytic targeting! The design and applications of catalytic metallodrugs as a novel therapeutic strategy are summarized and illustrated through examples of substrate-selective metal catalysts that target a variety of disease-related biomolecules. This strategy of promoting inactivation of a therapeutic target to a dysfunctional form may find promising applications in drug design and provide new modes of action of relevance to combination therapies.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701714

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.