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5 years ago

Correlative Microscopy: Site-Specific SERS Assay for Survivin Protein Dimer: From Ensemble Experiments to Correlative Single-Particle Imaging (Small 32/2017)

Correlative Microscopy: Site-Specific SERS Assay for Survivin Protein Dimer: From Ensemble Experiments to Correlative Single-Particle Imaging (Small 32/2017)
Sebastian Schlücker, Sandra Bäcker, Jörg Wissler, Alessandro Feis, Shirley K. Knauer
An assay for protein dimers using surface-enhanced Raman scattering (SERS) is presented, in article number 1700802, by Sebastian Schlücker and co-workers. Site-specific binding of the Survivin protein dimer to molecularly functionalized gold nanoparticles results in the formation of protein-bridged dimers of gold nanoparticles. The dimers exhibit the characteristic SERS spectrum of Raman reporter molecules in the hot spot generated upon resonant laser excitation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201770176

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