3 years ago

Integration of Biomolecules with Metal–Organic Frameworks

Integration of Biomolecules with Metal–Organic Frameworks
Allison P. Young, Jia Zhuang, Chia-Kuang Tsung
Owing to the progressive development of metal–organic-frameworks (MOFs) synthetic processes and considerable potential applications in last decade, integrating biomolecules into MOFs has recently gain considerable attention. Biomolecules, including lipids, oligopeptides, nucleic acids, and proteins have been readily incorporated into MOF systems via versatile formulation methods. The formed biomolecule-MOF hybrid structures have shown promising prospects in various fields, such as antitumor treatment, gene delivery, biomolecular sensing, and nanomotor device. By optimizing biomolecule integration methods while overcoming existing challenges, biomolecule-integrated MOF platforms are very promising to generate more practical applications. Integrating biomolecules into metal–organic-frameworks (MOFs) has recently gain considerable attention, owing to the progressive development of the synthesis of MOFs in the last decade. Biomolecules, including lipids, oligopeptides, nucleic acids, and proteins are readily incorporated into MOF systems via versatile formulation methods. The formed biomolecule-MOF hybrid structures show promising prospects in various fields, such as antitumor treatment, gene delivery, biomolecular sensing, and nanomotor device.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201700880

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