3 years ago

Copper-Promoted Desulfitative N-Arylation of Sulfonamides and Sulfoximines with Sodium Arylsulfinates

Copper-Promoted Desulfitative N-Arylation of Sulfonamides and Sulfoximines with Sodium Arylsulfinates
Wanrong Dong, Zhihong Peng, Yangji Jiang, Yaping You, Delie An, Yingjun Zhang
A general and direct N-arylation of sulfonamides and NH-sulfoximines by sodium arylsulfinates through a desulfitative pathway was herein demonstrated. The reaction proceeded with catalytic loadings of Cu(II)-catalysts without any external ligands. And the novel arylation protocol featured for high efficiency (up to 93% yields) and good substituent tolerance (up to 53 examples). Moreover, a plausible reaction mechanism was also discussed.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00633

DOI: 10.1021/acs.joc.7b00633

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