3 years ago

Two Diterpene Synthases for Spiroalbatene and Cembrene A from Allokutzneria albata

Patrick Rabe, Lukas Lauterbach, Jan Rinkel, Jeroen Sidney Dickschat
Two bacterial diterpene synthases from the actinomycete Allokutzneria albata were investigated, resulting in the identification of the structurally unprecedented compound spiroalbatene from the first and cembrene A from the second enzyme. Both enzymes were deeply investigated for their mechanisms by isotopic labelling experiments, site-directed mutagenesis, and variation of metal cofactors and pH. For spiroalbatene synthase the pH- and Mn2+-dependent formation of the byproduct thunbergol was observed that is biosynthetically linked to spiroalbatene.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201800385

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