Organic Letters
Organic Letters
5 years ago

Cinnamomols A and B, Immunostimulative Diterpenoids with a New Carbon Skeleton from the Leaves of Cinnamomum cassia

Cinnamomols A and B, Immunostimulative Diterpenoids with a New Carbon Skeleton from the Leaves of Cinnamomum cassia
Wei Tang, Lei Zhou, Yali Tuo, Junfen Zeng, Yu Zhou, Ming Xiang, Jianping Zuo, Xiaoman Guo, Yongbo Xue, Yi Hao, Guangmin Yao, Yonghui Zhang
Two diterpenoids with an unprecedented diterpene carbon skeleton, cinnamomols A (1) and B (2), were isolated from the leaves of Cinnamomum cassia. 1 and 2 feature a cage-like, rigid, 5/5/5/5/5/6-fused hexacyclic ring system. The structures of 1 and 2 were established by extensive spectroscopic techniques and single-crystal X-ray diffraction, and their plausible biosynthetic pathways were proposed. 1 and 2 exhibited significant in vitro immunostimulative activity, and the mode of action of 1 was investigated.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01323

DOI: 10.1021/acs.orglett.7b01323

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