3 years ago

Synthesis of α,β-Unsaturated Amidines through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

Synthesis of α,β-Unsaturated Amidines through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides
Shao-Xuan Zuo, Xin Liu, Hang-Hao Li, Chunyin Zhu, Long-Wu Ye, Te Zhang, Peng-Peng Ruan
A concise and flexible synthesis of α,β-unsaturated amidines via gold-catalyzed intermolecular ynamide amination/carbene 1,2-shift between ynamides and benzylic azides has been developed. Under mild reaction conditions, various α,β-unsaturated amidines were obtained in mostly good yields, thus providing an efficient and atom-economic way for the construction of valuable α,β-unsaturated amidines.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01689

DOI: 10.1021/acs.joc.7b01689

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