3 years ago

Cobalt-Catalyzed Oxidant-Free Spirocycle Synthesis by Liberation of Hydrogen

Cobalt-Catalyzed Oxidant-Free Spirocycle Synthesis by Liberation of Hydrogen
Zhanxiang Liu, Yue Liu, Ningning Lv, Chunhua Xiong, Yuhong Zhang
The first example of oxidant-free cobalt-catalyzed synthesis of five-membered spirocycles is reported from benzimidates and maleimides utilizing nitrobenzene as promoter. In contrast to previously known cobalt-catalyzed oxidative C–H functionalization reactions, this transformation occurs efficiently in the absence of oxidant and is accompanied by liberation of hydrogen. The spiro-lactams were readily achieved by the hydrolysis of as-prepared spirocyclic compounds. The Cp*Rh(III) catalyst shows poor reactivity.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02266

DOI: 10.1021/acs.orglett.7b02266

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