Organic Letters
Organic Letters
5 years ago

CuCl/Et3N-Catalyzed Synthesis of Indanone-Fused 2-Methylene Pyrrolidines from Enynals and Propargylamines

CuCl/Et3N-Catalyzed Synthesis of Indanone-Fused 2-Methylene Pyrrolidines from Enynals and Propargylamines
Lianfen Chen, Huanfeng Jiang, Shifa Zhu, Shaotong Qiu
An efficient CuCl/Et3N-catalyzed tandem reaction for the synthesis of indanone-fused pyrrolidine was developed. In this process, two rings and four bonds are generated in one pot with high atom-economy and step-efficiency. The addition of Et3N was found as the key factor for the success of the tandem reaction.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02121

DOI: 10.1021/acs.orglett.7b02121

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